Receptor Desensitization & Ca2+-Signaling Cellular Aspects of Possible Molecular Dynamics by M. K. Uchida

Cover of: Receptor Desensitization & Ca2+-Signaling | M. K. Uchida

Published by Japan Scientific Societies Press .

Written in English

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  • Biochemistry,
  • Cellular biology,
  • Molecular biology,
  • Pharmacology,
  • Science/Mathematics,
  • Science,
  • Life Sciences - Zoology - General,
  • Mechanics - Dynamics - General

Book details

The Physical Object
Number of Pages213
ID Numbers
Open LibraryOL8938248M
ISBN 103805562837
ISBN 109783805562836

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Receptor desensitization can involve phosphorylation of the receptor itself. The increase in cAMP levels as a result of ligand binding to the receptor leads to an activation of protein kinase A.

Protein kinase A can phosphorylate target proteins as well as cytosolic serine and threonine residues in the receptor itself. We recently described a Receptor Desensitization & Ca2+-Signaling book receptor cross-talk mechanism in neutrophils, exclusive for the reason that the indicators generated with the PAF receptor (PAFR) as well as the ATP receptor (P2Con2R) transfer formyl peptide receptor 1 (FPR1) from a desensitized (non-signaling) condition back again to an actively signaling condition (Forsman H em et al.

of FPR2, and it activates aswell as. Receptor phosphorylation by receptor-specific kinases and the binding of various cellular adaptor proteins also regulates receptor desensitization, internalization, sequestration, and recycling.

Molecular Mechanism of Store-Operated Ca2+ Signaling and CRAC Channel Activation Mediated by STIM & Orai.

Book chapter Full text access. Books Physical & Theoretical, Organic, Analytic, Inorganic and more from the wide range of products, online shopping at best prices. Role of Ca2+ dynamics and Ca2+ sensitization in the regulation of airway smooth muscle tone. Ca2+ signaling via Ca2+ dynamics and Ca2+ sensitization contributes to the functional antagonism between β2-adreneceptor agonists and contractile agonists (such as Cited by: 5.

A New Mode of Ca2+ Signaling by G Protein-Coupled Receptors Article in Current Biology 13(10) · May with 19 Reads How we measure 'reads'. Author(s): Uchida,Masaatsu K Title(s): Receptor desensitization and Ca2+-signaling: cellular aspects of possible molecular dynamics/ edited by Masaatsu K.

Uchida. Mar 10,  · Desensitization is a phenomenon that is common to many ligand-gated ion channels but has been demonstrated only rarely with physiological stimulation. Numerous studies describe desensitization of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor by exogenous agonists, but whether synaptic stimulation causes desensitization has been by: Receptor-triggered release of Gβγ within these complexes could initiate and/or facilitate activation of the sub-set of IP 3 Rs that function as a trigger pool to launch [Ca 2+] i oscillations and Ca 2+ waves.

In summary, the present work provides evidence for IP 3-independent regulation of IP 3 Rs by by: A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text.

Research and Development for Anti-Asthmatic Agents with a Focus on Phenotype Changing by Ca2+ Signaling in Airway Smooth Muscle Cells bronchodilaters such as β2-adrenoceptor agonists and muscarinic receptor antagonists do not clinically improve eosinophilic inflammation.

airway hyperresponsiveness, β2-adrenergic desensitization, and Author: Hiroaki Kume. Little is known about receptor regulation in neurons. Therefore, we examined the effects of the neurotransmitter substance P (SP) on desensitization of the neurokinin-1 receptor (NK1-R) and on the subcellular distribution of NK1-R, G αq/11, GRK-2 and -3, and β-arrestin-1 and -2 in.

Nov 14,  · Feedback regulation of receptor-induced Ca2+ signaling mediated by E-Syt1 and Nir2 at endoplasmic reticulum-plasma membrane junctions.

Chang CL(1), Hsieh TS, Yang TT, Rothberg KG, Azizoglu DB, Volk E, Liao JC, Liou J. Author information: (1)Department of Physiology, UT Southwestern Medical Center, Dallas, TX Receptor Desensitization & Ca2+-Signaling book, by: Oct 24,  · Abstract.

In Drosophila photoreceptor cells, Ca 2+ exerts regulatory functions that control the shape, duration, and amplitude of the light response. Ca 2+ also orchestrates light adaptation allowing Drosophila to see in light intensity regimes that span several orders of magnitude ranging from single photons to bright sunlight.

The prime source for Ca 2+ elevation in the cytosol is Ca 2 Author: Olaf Voolstra, Armin Huber. The G protein/K Ca channel processes may contribute to an increase in response to muscarinic receptor agonists (airway hyperresponsiveness) [22,23] and a decrease in response to β 2-adrenoceptor agonists (β 2-adrenoceptor desensitization) [51,52].

We examined involvement of these processes in this synergistic by: 5. However, desensitization is not observed in perforated-patched cells and in two-electrode voltage clamped oocytes. Addition of ATP, but not ATPγS or GTP, in the pipette solution also abolishes progressive desensitization, whereas intracellular injection of apyrase facilitates receptor desensitization.

"This volume reprints 53 articles originally published in by Elsevier in The researchers describe the structure and role of cell surface receptors in signaling activities with separate sections on tyrosine kinase, cytokine, G.

Jun 20,  · Abstract. The generation of a synaptic current at the postsynaptic element (PSCs) is the result of a dynamic sequence of events including the release of the neurotransmitter, its diffusion in the synaptic cleft, and the activation of neurotransmitter receptors located at the postsynaptic by: 1.

Organization of the book is aimed at striking a balance between the biochemistry 2 and physiology of normal cell Ca + metabolism and the pathological consequences of al­ 2 terations in cell Ca + homeostasis. Receptor-Mediated Ca2+ Signaling. Pages Receptor Desensitization Is a Major Regulator of Hormone-Induced Ca2.

Recent Publications. ORIGINAL RESEARCH PAPERS (present) R.A.J. () Defining the roles of arrestin2 and arrestin3 in vasoconstrictor receptor desensitization in hypertension.

Physiol. R.A.J. () Effects of positive allosteric modulators on single cell oscillatory Ca2+ signaling initiated by the type 5 metabotropic. Embodiments of the present invention provide compositions for controlling a target pest including a first agent and a second agent comprising a pest control product or a signal cascade modulator, wherein the first agent and the second agent act synergistically to control the target pest.

The first agent can be capable of interacting with a receptor in the target 埃萨姆·埃南. Oct 13,  · The role of receptor internalization in signal transduction is not completely resolved.

It is generally assumed that receptor internalization is a mechanism of ligand-induced desensitization (Ferguson et al., ). However, recent data suggest that activation of specific signaling pathways requires receptor internalization (Daaka et al., About.

Fredrick Van Goor, Ph.D., is the Vice President and Head of Cystic Fibrosis (CF) Research for Vertex Pharmaceuticals CF drug discovery program and he provides scientific leadership for the Title: Vice President and Head of Cystic.

Agonist-mediated regulation of histamine H1 receptors and Ca2+ signaling: Ca2+/calmodulin-mediated regulation of receptor function and distribution (S.

Hishinuma). Involvement of protein kinase C in regulation of histamine H1 receptor expression in U astrocytoma cells (R. Ishikawa et al.). Professional Summary: We investigate the activation mechanisms of fast neurotransmitter receptors.

We seek to define the activation pathway, modulatory mechanisms and structure-function relationships of the N-methyl-D-aspartate (NMDA) receptor to better understand the roles played by this protein in the brain. Abstract. Proteinase-activated receptor 2 (PAR-2) belongs to a novel family of G-protein coupled receptors that are unique in their activation mechanism by which a proteolytic cleavage at N-terminus by a proteinase reveals a ‘tethered ligand’ to activate the Jian Gan.

Sustained disruptions in Ca2+ signaling have significant implications for the health and functionality of neurons and form the basis of the Ca2+ hypothesis of AD.

Under resting conditions, cytosolic Ca2+ is maintained at low nanomolar concentrations by an array of pumps, buffers, and transport by: Jun 16,  · I suppose I thought for a while that if I was talking about dopamine and serotonin and GABA and things enough, people would just kind of "get" neurotransmission.

And most people do. But it's still a good thing to cover, partially because it's kind of mind boggling to think about (well, Sci finds it mind-boggling). Apr 15,  · ATP is known to act as an extracellular messenger mediating the propagation of Ca2+ waves in astrocyte networks.

ATP mediates Ca2+ waves by activating P2Y purinoceptors, which mobilize intracellular Ca2+ in astrocytes. A number of P2Y purinoceptor subtypes have been discovered, but it is not known which P2Y subtypes participate in transmitting astrocyte Ca2+ by: Receptor downregulation involves a decrease in the density of cell surface receptors and is a slow process that occurs over a pe riod of hours to days [, ] In contrast, receptor desensitization involves a tempor ary loss of receptor responsiveness to agonist and is a rapid process that begins within seconds of agonist binding [, ].

The third intracellular domain of the platelet-activating factor receptor is a critical determinant in receptor coupling to phosphoinositide phospholipase C-activating G proteins.

Studies using intracellular domain minigenes and receptor chimeras. The Journal of biological chemistry, (38). "Phenotypic changes in mouse pancreatic stellate cell Ca2+ signaling events following activation in culture and in a disease model of pancreatitis." -terminal threonine residues in human m3 muscarinic acetylcholine receptor modulates the extent of sequestration and desensitization." Molecular pharmacology.

Sep 0; 48(3) Small-Molecule Inhibitors of the Receptor Tyrosine Kinases Promising Tools for Targeted Cancer Therapies. Sample Page; Category: ATPase Background Novobiocin is a coumarin antibiotic, which impacts also eukaryotic cells 12/16/ molecularcircuit Comments Closed.

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SMOLEN LAURENCE A. BOXER Chemotaxis and Motility Ingestion Adhesion Molecules Granules Types of Granules Function of Granules Stimulus-Response Coupling Receptor-Ligand Interactions G-Proteins Phospholipid Metabolism Calcium Protein Kinases.

Figure I Receptor desensitization. Ras-MAPK, cAMP-PKA and Ca2+-signaling. Figure II Convergence of signaling pathways (4) Transcription factors.

Finally, as we have already discussed in Chapter I, transcription factors interact to control the activity of the transcription machinery. For example, the GR can interact with AP G protein-coupled receptors (GPCRs) are the largest protein family for cell signal transduction, and most of them are crucial drug targets.

Conventional label-free assays lack the spatial information to address the heterogeneous response from single cells after GPCRs activation. Here, we reported a GPCRs study in live cells using plasmonic-based electrochemical impedance by: 1.

Conformational dynamics plays a critical role in the activation, deactivation, and open–close activities of ion channels in living cells.

Such conformational dynamics is often inhomogeneous and extremely difficult to be directly characterized by ensemble-averaged spectroscopic imaging or only by single channel patch-clamp electric recording by: Oct 18,  · Jerrel Yakel 1. Fayuk, D. & Yakel, J.L. () Dendritic Ca2+ signaling due to activation of α7-containing nicotinic acetylcholine receptors in rat hippocampal neurons.

J.L. () Calcium influx through voltage-gated calcium channels regulates 5-HT3 receptor channel desensitization in NG cells. Ann N Y Acad Sci.

Histamine Research in the New Millennium by T. Watanabe,available at Book Depository with free delivery worldwide. Regulation of Ca2+ Signaling and Ca2+-Sensitive Functions of Mouse Dendritic Cells by AMP-Activated Protein Kinase and Klotho Protein Dissertation der Mathematisch-Naturwissenschaftlichen FakultätAuthor: Meerim Nurbaeva.Neuropeptide receptors of the brain and spinal cord are parts of the pain circuits targeted by analgesic drugs.

Some of these receptors have been found in the central nervous system as well as in intracranial vascular structures and achieved revival of attention because of their role in acute and chronic pain syndromes.

A number of them are of high clinical relevance for e.g. by: 1.Mar 08,  · 1. A chimeric polypeptide, said chimeric polypeptide comprising: a) a first domain consisting essentially of third intracellular loop (i3 loop) or a fragment thereof of a G protein coupled receptor (GPCR), and b) a second domain, attached to the first domain, wherein said second domain is a naturally or non-naturally occurring cell-penetrating, membrane-tethering hydrophobic moiety wherein.

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